Our History

In 1972, University Hospital opened its doors and within six months surgeons had performed the hospital's first kidney transplant.

Researchers working with the LHSC Transplant Program began conducting test-tube experiments to manipulate the body's immune system and prevent organ rejection. In 1979, the drug company that discovered cyclosporine chose our hospital as one of the first centres worldwide to conduct a clinical study using this new anti-rejection medication. With the advent of cyclosporine, transplantation was on the rise.

In 1981, 14 months after the cyclosporine trials began, physicians noticed a significant decrease in organ rejection. The success of kidney transplants jumped from 50 per cent to 80 per cent survival one year after surgery.


Opening of Transplant Unit, 1987

 

 

 

 

 

 

 

 

 

 

 

London Health Sciences Centre added to kidney transplants with liver transplants (1977), heart transplants (1981), small bowel transplants (1988), and lung transplants (1989). The first bone marrow transplant at LHSC was performed in 1989 to treat a patient with leukemia.

By 1987, our hospital had established itself internationally as a centre for multi-organ transplantation. The Ministry of Health recognized this status by granting funds to build the 12-bed Multi-Organ Transplant Unit.

Our longest-surviving kidney transplant recipient is celebrating more than 35 years of healthy life. Some of our earliest patients are Canada's longest surviving liver and heart transplant recipients, now celebrating 30 years of healthy life after their transplants in the early 1980s. When the 600th heart transplant was performed at LHSC in 2012, our centre had performed more heart transplants than any other centre in Canada.

Nurses in Transplant Unit, late 1980s

Innovation has been a hallmark of our Multi-Organ Transplant Program. To address the shortage of donated organs, surgeons at LHSC have split livers from deceased donors into two halves so each half could be transplanted into separate recipients, suitably size-matched for the grafts. In 1993, a mother donated a piece of her liver so it could be transplanted into her infant son. Seven years later, in another Canadian first, that technique was extended to adult recipients by taking the larger right half of the liver from a living donor and transplanting it into an adult recipient.

bar graph, Growth of Transplantation in London

Our program's participation in cutting-edge discoveries has led to many transplant "firsts":

Transplant Firsts at LHSC
First liver transplant in Ontario (1977)
University Hospital is chosen as one of the first centres worldwide to begin a clinical study on the new anti-rejection drug, cyclorsporine (1979)
First heart transplant in Ontario (1981)
Canada's first heart-lung transplant (1983)
First pediatric heart transplant in Ontario (1983)
First pediatric liver transplant in Ontario (1984)
World's first successful liver-bowel transplant (1988)
Canada's first "cluster" (liver, bowel, stomach, pancreas) transplant (1990)
Canada's first parent-to-child living donor liver transplant (1993)
World's youngest multi-organ recipient (1997)

Canada's first adult-to-adult living donor liver transplant (2000)

First DCD liver donor in Canada (2006)
First DCD pancreas donor in Canada (2008)
First pediatric DCD kidney transplant in Canada (2008)
Another Canadian first: split pancreas with kidney transplant (2011)
600th heart transplant is done, the most of any Canadian centre (2012)
Robotic-assisted, single-incision living donor kidney nephrectomy, first in Canada (2013)

To find out more, you can read Three Decades of Transplantation, which provides an historical overview.

 

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Last Updated October 7, 2013 | © 2007, LHSC, London Ontario Canada