Name: METHOTRIMEPRAZINE (NozinanR)
Classification: phenothiazine; neuroleptic
  • antipsychotic
  • anxiolytic
  • sedative and analgesic properties
Dose:
  • Bolus: 
    • 5-25 mg IV direct
  • Infusion: 
    • 2-8 mg/hr, titrated to patient response
Administration: IV Infusion: 
50 mg/50 ml D5W, NS for syringe pump infusion or 100mg/100ml D5W, NS
Adverse Effects:
  • anticholinergic effects:
    • urinary retention
    • tachycardia
  • orthostatic hypotension
  • drowsiness
  • agranulocytosis (rare)
  • altered thermic response (poikilithermic effect) thus may not be able to adapt to temperature changes
Cautions:
  • in patients with glaucoma, due to anticholingergic effects
  • in epileptic patients due to possible reduction of seizure threshold
Drug Interactions:
  • methotrimprazine + epinephrine = diminished effect of epinephrine on blood pressure
  • methotrimprazine + CNS depressants = increased CNS depressant effects
Monitoring Therapy:
  • BP
  • HR, ECG
  • urine output
  • appropriate response to ambient temperature, temperature
  • white blood cell count
  • level of sedation
CCTC Protocol:
  • May be administered by IV infusion by an RN in CCTC.
Last Update: April 28, 2006


Lynne Kelly, Pharmacist, CCTC
Brenda Morgan, Clinical Nurse Specialist, CCTC
Last Update: August 7, 2006

LHSCHealth Professionals

Last Updated March 24, 2009 | © 2007, LHSC, London Ontario Canada