Other Inherited Bleeding Disorders

FACTOR (Other Name)

INCIDENCE

BLEEDING SEVERITY

Factor I (fibrinogen)

1 in 1,000,000

Usually mild, except with complete absence of fibrinogen

Factor II (prothrombin)

1 in 1,000,000

Usually mild

Factor V (parahemophilia)

1 in 1,000,000

Usually mild

Combined F V and F VIII

1 in 1,000,000

Usually mild

Factor VIII (Alexander’s)

1 in 1,000,000

Severe when Factor VII levels are low

Factor VIII (Hemophilia A)

1 in 10,000

Severe when Factor VIII levels are below 1%

Factor IX (Hemophilia B)

1 in 50,000

Severe when Factor IX levels are below 1%

Factor X (Stuart-Prower)

1 in 500,000

Moderate to severe when Factor X levels are below 10%

Factor XI (Hemophilia C)

1 in 100,000

Mild to moderate when Factor XI levels are below 15%

Factor XIII

1 in 3,000,000

Severe

There are several inherited bleeding disorders which although rare and generally mild in severity may affect the quality of life.  As you can see from the summary above the most common bleeding disorders are Factor VIII and Factor IX and because the other clotting factor deficiencies are so rare, tests are first done to rule out von Willebrand disease, platelet function disorders, and hemophilia A and B as the cause of bleeding. If one of the rare factor deficiencies is suspected, a laboratory assay is done to measure the level of the specific clotting factor.  These tests are done in a lab which specializes in bleeding disorders like the lab associated with the Bleeding Disorders Program.

For more information please visit the Canadian Hemophilia Society Website:  http://www.hemophilia.ca/en/bleeding-disorders

 

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Last Updated June 17, 2013 | © 2007, LHSC, London Ontario Canada