- cefazolin is a "first generation" semisynthetic cephalosporin antibiotic which has activity against Gram-positive bacteria and some Gram-negative bacteria
- the antibacterial activity of cefazolin, like the penicillins, results from the inhibition of bacterial cell wall synthesis
- cefazolin is eliminated unchanged in the urine
- first generation cephalosporins are usually active in vitro against Gram-positive cocci (S. aureus, S. epidermidis, Streptococcus pyogenes, group B Streptococci and Streptococcus pneumoniae);
- first generation cephalosporins have limited activity against Gram-negative organisms
The Following Organisms are Resistant
- enterococci, methicillin-resistant staphylococci, Bacteroides fragilis, Enterobacter, Listeria monocytogenes, Pseudomonas, Providencia and Serratia
- cefazolin does NOT penetrate into the CNS
- hypersensitivity reactions (eg. fever, rash, urticaria)
- positive direct and indirect Coombs' test results have been reported
- transient elevation of liver enzymes
- rare hematologic effects which have been reported include mild and transient neutropenia and thrombocytopenia
|< 2,000 g|| ||20 mg/kg q12h|
| || || |
|> 2,000 g||< 7 days||20 mg/kg q12h|
| ||> 7 days||20 mg/kg q8h|
- give by slow IV infusion
- COMPATIBLE WITH TPN AND LIPID
- 20 mg/mL syringe prepared by Pharmacy
- available in a 1g vial - add 4.5mL sterile water for injection to make a solution of
200 mg/mL. Add 1 mL of this solution to 9 mL sterile water for injection. This will produce a final concentration of 200 mg/10 mL (20mg/mL) which may be added to a running IV and given by slow infusion.
- McEvoy G K (ed): AHFS Drug Information, American Society of Hospital Pharmacists, 1991.
- Bhatt DR, Furman GI, Reber DJ et al: Neonatal Drug Formulary, 1990-1991, 2nd Edition, Fontana, California 92334.
- Taketomo CK, Hodding JH and Kraus DM: Pediatric Dosage Handbook, Lexi-Comp Inc., Cleveland, 1992.
- Ford DC, Leist ER and Phelps SJ: Guidelines for administration of intravenous medications to pediatric patients, American Society of Hospital Pharmacists, Bethesda, MD, 1988.
- Yaffe SJ and Aranda JV (Eds): Pediatric Pharmacology-Therapeutic Principles in Practice, WB Saunders Co, Toronto, Ontario 2nd Edition, 1992.
- "Ancef(R)", package insert, Smith Kline Beachan Inc, Oakville, Ontario.