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Disclaimer to the On-line Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.

DEXTROSE
(Glucose)

Indication

  • the treatment of acute symptomatic hypoglycemia

Side Effects

  • if administered too rapidly, local pain, and rarely, vein irritation may occur
  • rebound hypoglycemia
  • hyperglycemia and glycosuria may result from too rapid administration or metabolic insufficiency
  • dehydration (if glycosuria present)

Precautions

  • glucose can cause tissue necrosis; it can and also predispose the infant to rebound hypoglycemia
  • hyperglycemic patient is predisposed to monilial and fungal infections
  • test urine for glucose; dextrostix as ordered
  • be aware of serum glucose levels

Dose

  • 10% DEXTROSE: 2-4 mL/kg IV, followed by an infusion of 10% dextrose at 6 to 8 mg/kg/min (85 to 110 mL/kg/day)

Supplied

  • 10% ampoules (3 mL) and bags

References

  1. McEvoy G K (ed): AHFS Drug Information, American Society of Hospital Pharmacists, 1991.
  2. Gomella TL (Ed): Neonatology - Management, Procedures, On-Call Problems, Diseases, Drugs, 1992, Appleton and Lange, Norwalk, Connecticut.
  3. Bhatt DR, Furman GI, Reber DJ et al: Neonatal Drug Formulary, 1990-1991, 2nd Edition, Fontana, California 92334.



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