Disclaimer to the On-line Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.
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- test for myasthenia gravis ("Tensilon(R) Test")
- edrophonium is an anticholinesterase agent; it attaches to the enzyme acetylcholinesterase and thereby inhibits the hydrolysis of acetylcholine; acetylcholine may then accumulate at cholinergic synapses, resulting in generalized cholinergic responses, which include increased intestinal tone, bronchial constriction and bradycardia
- onset of action is 30-60 seconds following IV administration; duration of effect is 5-10 minutes
- arrhythmias (especially bradycardia), bronchospasm, hypotension, vomiting, diarrhea, respiratory paralysis
- gastrointestinal or genito-urinary mechanical obstruction
|NOTE:||HAVE ATROPINE AVAILABLE IN A SYRINGE (ATROPINE DOSE: 0.01 TO 0.03 mg/kg IV PUSH, MAY REPEAT EVERY 2 TO 10 MIN, MAXIMUM TOTAL DOSE 0.04 mg/kg) AND HAVE RESUSCITATION EQUIPMENT READY|
EDROPHONIUM DOSE AS A TEST FOR MYASTHENIA GRAVIS
- 0.04 mg/kg test dose IV push by physician only
- followed after 1 minute by 0.16 mg/kg IV push by physician only
- may be diluted to 1 mg/mL with a normal saline or dextrose solution just prior to use:
- Mix 1 mL of Edrophonium 10 mg/mL with 9 mL of normal saline or dextrose
|Concentration||=||10 mg/10 mL|
| ||=||1 mg/mL|
- McEvoy G K (ed): AHFS Drug Information, American Society of Hospital Pharmacists, 1991.
- Cloherty JP and Stark AR (eds): Manual of Neonatal Intensive Care, Little, Brown and Company, 1991.
- Trissel L.A.: Handbook on Injectable Drugs, American Society of Hospital Pharmacists 1988.
- Bhatt DR, Furman GI, Reber DJ et al: Neonatal Drug Formulary, 1990-1991, 2nd Edition, Fontana, California 92334.
- Taketomo CK, Hodding JH and Kraus DM: Pediatric Dosage Handbook, Lexi-Comp Inc., Cleveland, 1992.