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Disclaimer to the On-line Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.

NYSTATIN

Indication

  • used primarily to treat Candida infections of skin, mucous membranes and intestinal tract

Pharmacology

  • nystatin is both fungicidal and fungistatic; it is NOT active against bacteria, protozoa or viruses
  • acts by binding to sterols in the fungal cell membrane
  • very little nystatin is absorbed from the GI tract, mucous membranes or the skin
  • after oral administration virtually all of the drug is eliminated unchanged in the feces

Side Effects

  • infrequent; mild and transitory vomiting and diarrhea may occur

Dose

  • oral - 1 to 2 mL po Q6H
  • for treatment of oral thrush must be applied to the mucosa using a saturated Q-tip - the remaining amount of prescribed liquid should be given per N/G tube or be administered via a nipple in bottle-fed infants
  • topical - to buttocks and groin, applied Q6H

Supplied

  • 100,000 units/mL drops
  • 100,000 units/g ointment or cream

References

  1. McEvoy G K (ed): AHFS Drug Information, American Society of Hospital Pharmacists, 1991.
  2. Roberts, RJ: Drug Therapy in Infants, W.B. Saunders, Toronto, 1984.
  3. Bhatt DR, Furman GI, Reber DJ et al: Neonatal Drug Formulary, 1990-1991, 2nd Edition, Fontana, California 92334.



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