(Vitamin B 6)
- diagnosis and treatment of pyridoxine-dependent seizures (which may present in 1st 24 hours as intractable seizures)
- pyridoxine is essential in the synthesis of GABA, an inhibitory neurotransmitter in the CNS; thus, infants who have decreased concentrations of GABA will have a lower seizure threshold; the GABA deficiency will be corrected with pharmacologic doses of pyridoxine
- seizures will normally stop within 10 minutes of IV administration
- normalization of the EEG may take minutes to several weeks after pyridoxine therapy is begun
- pyridoxine is also involved in protein, carbohydrate and fat metabolism
- considered relatively non-toxic
- sensory neuropathy may result from chronic administration of very large doses
INITIAL DIAGNOSTIC DOSE
- 100mg IV push under EEG monitor (by physician only), followed by a 30 minute observation period
FOR PYRIDOXINE-DEPENDENT INFANTS; ie. to prevent pyridoxine-dependent seizures
- 50 to 100 mg/day po, given once daily
- 100 mg/mL, 1 mL ampoule
- 50 mg/mL oral solution, prepared by Pharmacy
- McEvoy G K (ed): AHFS Drug Information, American Society of Hospital Pharmacists, 1991.
- Roberts, RJ: Drug Therapy in Infants, W.B. Saunders, Toronto, 1984.
- Gomella TL (Ed): Neonatology - Management, Procedures, On-Call Problems, Diseases, Drugs, 1992, Appleton and Lange, Norwalk, Connecticut.
- Taketomo CK, Hodding JH and Kraus DM: Pediatric Dosage Handbook, Lexi-Comp Inc., Cleveland, 1992.
- Young TE and Mangum OB: Neofax - A Manual of Drugs Used in Neonatal Care, Columbus, Ohio: Ross Laboratories, 1992.