- used for the treatment of edema (eg. caused by heart failure or associated with bronchopulmonary dysplasia) and mild to moderate hypertension
- a combination of 2 diuretics (spironolactone and hydrochlorothiazide) with different but complementary mechanisms of action
- hydrochlorothiazide enhances excretion of Na, Cl and water by inhibiting their reabsorption at the cortical diluting segment of the renal tubule; K excretion is increased because of the increased amount of Na which reaches the distal tubular site of Na-K exchange
- spironolactone inhibits the effects of the adrenocortical hormone, aldosterone, by interfering with the aldosterone-dependent Na-K exchange site in the distal tubule; this results in increased excretion of Na, Cl and water and decreased excretion of K; therefore spironolactone is termed a "potassium-sparing diuretic"
- fluid and electrolyte imbalance: hyper- or hypokalemia, hyponatremia; dehydration
- may cause hyperglycemia, thrombocytopenia, vomiting, diarrhea, drowsiness, lethargy
- 1 to 2 mg/kg (hydrochlorothiazide/spironolactone suspension) po q12h
- 5 mg/mL oral suspension (each mL contains 5 mg each of hydrochlorothiazide and spironolactone) prepared by Pharmacy.
- McEvoy G K (ed): AHFS Drug Information, American Society of Hospital Pharmacists, 1991.
- Krogh CME et al (ed): Compendium of Pharmaceuticals and Specialties, Canadian Pharmaceutical Association, 1992.