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Disclaimer to the On-line Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.

VERAPAMIL

THE USE OF VERAPAMIL IN INFANTS IS CONTROVERSIAL. THE POSSIBILITY OF IRREVERSIBLE SIDE EFFECTS (PROFOUND BRADYCARDIA AND HYPOTENSION) HAS LIMITED ITS USE.

Indication

  • to control supraventricular tachycardia

Pharmacology

  • verapamil is a calcium-channel blocking agent
  • exerts a negative chronotropic effect, depresses automaticity and conduction

Side Effects

  • hypotension, bradycardia, 1st, 2nd, or 3rd degree A-V block
  • may increase serum digoxin concentrations

Precautions

  • monitor heart rate and blood pressure continuously during administration of this drug
  • use may be contraindicated in cases of congestive heart failure caused by hydrops

Dose

  • 0.1 to 0.3 mg/kg (100 to 300 mcg/kg) IV push over 2 minutes, given by a physician only; this dose may be repeated in 30 minutes

Supplied

  • 2.5 mg/mL, 2 mL ampoule

References

  1. Cloherty JP and Stark AR (eds): Manual of Neonatal Intensive Care, Little, Brown and Company, 1991.
  2. Roberts, RJ: Drug Therapy in Infants, W.B. Saunders, Toronto, 1984.
  3. Gomella TL (Ed): Neonatology - Management, Procedures, On-Call Problems, Diseases, Drugs, 1992, Appleton and Lange, Norwalk, Connecticut.
  4. Taketomo CK, Hodding JH and Kraus DM: Pediatric Dosage Handbook, Lexi-Comp Inc., Cleveland, 1992.



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