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The liver, which is the body's largest internal organ, is located in the right upper part of the abdomen under the diaphragm. The liver is divided into two sections, the right lobe and the left lobe. The gallbladder, which stores bile produced by the liver, is attached below the right lobe. Blood comes from the intestine and enters the portal vein, then passes through the liver before returning to the heart and lungs to be oxygenated.

The liver performs several important functions:
Liver failure means the liver is no longer adequately performing these functions.