• used as induction agent for intubation as general sedative or in rapid sequence induction
• rapid onset of action usually within 60 seconds (may be 5-15 seconds) with duration of action of 3-5 minutes (may be up to 14 minutes)
• no analgesic activity; minimal respiratory or cardiovascular effects
• special access product

• 0.3 mg/kg to usual maximum of 20 mg IV
• may require dose reduction in elderly patients

use large proximal arm veins or central line if possible to avoid pain on injection

• injection site pain
• transient skeletal muscle movements including myoclonus
• hypo-/hyperventilation, apnea
• arrhythmias
• laryngospasm
• nausea/vomiting
• prolonged suppression of cortisol and aldosterone synthesis with continuous infusion or repeated dosing

• ECG, HR
• BP
• respiratory rate, SpO₂

• Must be administered by MD trained in airway management with patient specific approval from senior resident or CCTC consultant.
• monitoring sheet must be completed by administering physician and returned to Pharmacy Department.