Name: ADENOSINE (AdenocardR)
Classification: Antiarrhythmic: 
  • produces short acting AV block to aid in the diagnosis of supraventricular tachycardias
  • may convert PSVT to sinus rhythm when verapamil is not effective or is contraindicated
Dose: Bolus Dose:
  • 6 mg IV rapid bolus
  • may repeat with 12 mg IV bolus every 1-2 minutes to a maximum total dose of 30 mg
  • should be given as close to the site, and as quickly as possible
Administration: IV Infusion:
  • rapidly undiluted as bolus BDC
Adverse Effects:
  • cardiovascular
    • sinus bradycardia, sinus arrest, atrial fibrillation, AV block (usually < 1 minute)
    • hypotension
  • non-cardiovascular
    • flushing and dyspnea
    • headache, cough, malaise, or nausea usually lasting <1 minute due to very short half life
Drug Interactions:
  • adenosine + aminophylline/theophylline = decreased adenosine effect
  • adenosine + digoxin = bradycardias and increased AV blocks
  • adenosine + verapamil = bradycardias and increased AV blocks
  • adenosine + beta blockers = bradycardias and increased AV blocks
Monitoring Therapy:
  • ECG, rhythm
  • blood pressure
CCTC Protocol:
  • Must be administered  by a physician in CCTC.
  • This drug must be given by rapid BDC bolus.

Lynne Kelly, Pharmacist, CCTC
Brenda Morgan, Clinical Nurse Specialist, CCTC
Last Update: August 7, 2006

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Last Updated March 24, 2009 | © 2007, LHSC, London Ontario Canada