Use with caution in patients concomitantly receiving
other anticoagulants or antiplatelet agents, or at increased risk
of hemorrhage (eg. post major surgery or procedure, HTN)
No known reversal agent available; if required, discontinue
infusion and coagulation parameters should return to baseline within
CONVERSION TO WARFARIN THERAPY:
Do not give loading dose of warfarin; initiate therapy with
expected daily dose of warfarin.
Agratroban dose up to 2 mcg/kg/min: discontinue
argatroban infusion when INR >4.
Repeat INR measurement in 4 to 6 hours. If repeat INR is
below the desired therapeutic range, resume argatroban infusion
at previous rate and repeat the procedure daily until the desired
therapeutic range on warfarin alone is reached.
Agratroban dose greater than 2 mcg/kg/min: once
INR>4, reduce argatroban infusion to 2 mcg/kg/min. Repeat the INR 4 to 6 hours after
reduction of the argatroban dose and follow the process outlined
above for administering argatroban at doses up to 2 mcg/kg/minutge