Name: DIAZOXIDE(HyperstatR)
Classification: antihypertensive agent
  • relaxes smooth muscle in the peripheral arterioles resulting in decreased blood pressure and increased cardiac output
  • can be used to treat hypoglycemia induced by oral hypoglycemic agents (eg. glyburide) as produces a prompt dose-related increase in blood glucose level, due primarily to an inhibition of insulin release from the pancreas and also to an extrapancreatic effect
Dose: Bolus doses:
  • 1-3 mg/kg q5-15 min to a total of 300 mg; OR
  • 50 mg q5 min to a total of 300 mg
Administration:
  • administer rapidly undiluted as IV direct bolus.
  • slow infusion of diazoxide may be used in non-emergent situations: 15-30 mg/min over 20-30 minutes
Adverse Effects:
  • increased blood glucose: effect is potentiated in the presence of hypokalemia
  • tachycardia
  • hypotension
  • decreased CO
  • myocardial ischemia
  • cellulitis/phlebitis: may result from extravasation as solution is highly alkaline
Drug Interactions:
  • diazoxide + diuretics = increased hyperglycemic and hypotensive effect
  • diazoxide + corticosteroids = increased hyperglycemic effect
Monitoring Therapy:
  • HR
  • arterial blood pressure
  • blood glucose
  • ECG
  • electrolytes
CCTC Protocol:
  • May be administered IV direct by an approved nurse in CCTC providing the drug administration rate does not exceed 50mg/10 seconds and total dose does not exceed 300mg.


Lynne Kelly, Pharmacist, CCTC
Brenda Morgan, Clinical Nurse Specialist, CCTC
Last Update: August 7, 2006

LHSCHealth Professionals

Last Updated March 24, 2009 | © 2007, LHSC, London Ontario Canada