||GLUCAGON HCL (GlucagonR)
- increases blood glucose concentrations by converting hepatic glycogen to glucose
- produces relaxation of the smooth muscle of the stomach, duodenum, small bowel and colon; used in diagnostic tests requiring a hypotonic state
- has inotropic and chronotropic effects, possibly by stimulating the release of catecholamines; can be used to counteract the symptoms of beta blocker overdose
- 1 mg = 1 unit
- for severe hypoglycemia or termination of insulin shock: 0.5-1 mgIM, SC or IV q 5-25 minutes to a maximum of 3 doses
- as a diagnostic aid: 1-2 mg IM or 0.25-2 mg IV depending on desired onset of action and desired duration of effect
- for beta blocker overdose:
- bolus dose of 3-10 mg q10min as required
- infusion at 1-5 mg/hr, titrated to patient response
dilute in D5W for a final concentration of 0.1mg/ml
- use provided diluent only if dose <2 mg and for intermitten injection; otherwise use sterile water for injection, then dilute further with D5W if reuired.
- nausea, vomiting
- increased HR, BP
- in patients with pheochromocytoma as may induce sudden release of large amounts of catecholamines from the tumour
- in patients with insulinoma as may induce tumour to release insulin, precipitating hypoglycemia
- glucagon + epinephrine = increased and prolonged hyperglycemic effect of glucagon
- May be administered by IM, SC or by IV infusion by an approved nurse in CCTC.
- Continuous infusion must be administered via an infusion pump.