Name: ISOPROTERENOL (IsuprelR)
Classification: sympathomimetic

stimulates beta adrenergic receptors

  • positive inotrope
  • positive chronotrope
  • positive dromotrope
  • bronchodilator
  • causes vasodilation resulting in reduced peripheral vascular resistance (unlike epinephrine, has no alpha properties)
Dose:
  • Bolus dose:
    • 0.05 - 0.2 mg IV direct
  • Infusion:
    • 0.05 - 0.2 mcg/kg/min (approx. 1 - 4 mcg/min), titrate to effect
Administration:
  • IV Direct:
    • dilute 1 mL of 1:5000 (0.2 mg/mL) to a volume of 10 mL with NS/D5W (final concentration of 20 mcg/mL)
  • IV Infusion:
    • 5mg/250 mL NS, D5W, RL (20 mcg/ml)
  • hypovolemia, acidemia, and hypoxemia should be corrected concurrently with initiation of therapy
  • should be weaned off
Adverse Effects:
  • tachycardia
  • arrhythmias
  • hypotension or hypertension
  • increased myocardial oxygen consumption
  • increased blood glucose
when using to correct bradyarrhythmias or as an inotrope, monitor carefully for hypotension
Drug Interactions:
  • isoproterenol + theophylline = decreased serum theophylline levels
Monitoring Therapy:
  • HR, ECG rhythm
  • BP
  • urine output
  • cardiac index
  • blood gases
  • PWP
  • arterial lactate
  • blood glucose
  • electrolytes
CCTC Protocol:
  • May be administered by IV infusion by an approved nurse in CCTC.
  • May be titrated by an approved nurse in the CCTC.
  • Must be administered via a central line.
  • Continuous infusion must be administered via an infusion pump.
  • Should not be infused through the proximal injectate port (blue) of the Swan Ganz catheter.
  • Patient requires placement of an arterial line to monitor BP.


Lynne Kelly, Pharmacist, CCTC
Brenda Morgan, Clinical Nurse Specialist, CCTC
Last Update: January 12, 2017

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Last Updated January 12, 2017 | © 2007, LHSC, London Ontario Canada