- relaxes arterial and venous smooth muscle to decrease preload with mild afterload reduction; venous effect > arterial
- decreases pulmonary vascular resistance
- coronary vasodilation
- improves ventricular compliance
50mg/250 mL D5W or NS (maximum concentration: 200mg/250 mL)
- mix in glass bottle (adsorbed onto polyvinyl chloride)
- hypovolemia should be corrected concurrently with initiation of therapy
- drug should be weaned off (abrupt discontinuation may cause rebound coronary artery spasm)
- headache, flushing
- pulmonary vasodilation may worsen pulmonary shunt
- PWP, PAP, PVRI
- chest pain
- cardiac index
- blood gases, Sp02, pulmonary secretions
- CVP, SVRI
- HR, ECG rhythm
- arterial lactate
- urine output
- May be administered by IV infusion by an approved nurse in CCTC.
- May be titrated by an approved nurse in CCTC.
- Continuous infusion must be administered via an infusion pump.
- Should not be infused into the proximal injectate port (blue) of the Swan Ganz catheter.
- Patient requires placement of an arterial line to monitor BP.
Lynne Kelly, Pharmacist, CCTC
Brenda Morgan, Clinical Nurse Specialist, CCTC
Last Update: August 7, 2006, October 25, 2011