Name: PANTOPRAZOLE (PantolocR)
Classification: proton pump inhibitor (PPI) 
  • inhibits the gastric H KATPase enzyme (the proton pump) that is responsible for acid secretion by the parietal cells of the stomach, resulting in increased gastric pH 
  • increased gastric pH desired for the prevention of stress-induced gastric ulceration and in the promotion of coagulation and platelet function in bleeding peptic ulcer disease 
  • maintenance dose: 40 mg IV once daily or BID
  • bleeding peptic ulcer:  80 mg IV bolus followed by continuous infusion at 8 mg/hr
may need to decrease dose if significant hepatic dysfunction
  • Bolus:  40-80 mg in 100 ml NS infused over 15-60 minutes
  • Infusion: 
    • 40 mg in 100 ml NS
    • bag stable only for 6 hours thus not recommended to prepare large size bag
Adverse Effects:


  • diarrhea
  • headache 
  • dizziness 
  • pruritus
  • asthenia
Monitoring Therapy:
  • bowel movements, stools for occult blood
  • skin condition
  • CCTC Protocol:
    • May be administered by IV infusion by an approved nurse in CCTC.
    • Must be administered as a continuous infusion via an infusion pump.

    Lynne Kelly, Pharmacist, CCTC
    Brenda Morgan, Clinical Nurse Specialist, CCTC
    Last Update: August 7, 2006

    LHSCHealth Professionals

    Last Updated March 24, 2009 | © 2007, LHSC, London Ontario Canada