• inhibits the gastric H KATPase enzyme (the proton pump) that is responsible for acid secretion by the parietal cells of the stomach, resulting in increased gastric pH 
• increased gastric pH desired for the prevention of stress-induced gastric ulceration and in the promotion of coagulation and platelet function in bleeding peptic ulcer disease 

• maintenance dose: 40 mg IV once daily or BID
• bleeding peptic ulcer:  80 mg IV bolus followed by continuous infusion at 8 mg/hr

• Bolus:  40-80 mg in 100 ml NS infused over 15-60 minutes
• Infusion: 
• 40 mg in 100 ml NS
• bag stable only for 6 hours thus not recommended to prepare large size bag

• diarrhea
• headache 
• dizziness 
• pruritus
• asthenia

bowel movements, stools for occult blood

skin condition

• May be administered by IV infusion by an approved nurse in CCTC.
• Must be administered as a continuous infusion via an infusion pump.