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Since hemoglobin is a protein, stroma free hemoglobin has colloid properties
which contributes to the plasma oncotic pressure. Therefore, many investigators have
felt that the concentration of hemoglobin must be kept less than 70 g/L, which is the
normal plasma protein level. Since blood typically has about twice as much
hemoglobin, the stroma free hemoglobin preparations should not carry as much oxygen
as blood. More recent investigations have used hemoglobin concentrations up to 100
g/L. Since this is hyper-osmotic, it serves both as a plasma expander and an oxygen
carrier. The hyper-osmotic effect is quickly diluted by mixing with blood, drawing fluid
from tissues, and by the hemoglobin travelling into the intravascular spaces.
Forward to Encapsulated Hemoglobin
Back to Adverse Reactions to Stroma Free Hemoglobin
| Return to Programs and Services | Questions? Comments? Contact David Schaus |
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| Copyright ©1996-2003 London Health Sciences Centre. Please read our disclaimer | |