Fred Dick, PhD

Fred Dick

 

Distinguished Scientist: London Regional Cancer Program, London Health Sciences Centre, London, Ontario
Professor: Dept of Biochemistry

Western University, London, Ontario
Cross Appointment: Dept of Oncology

 

University Website

http://publish.uwo.ca/~fdick/Lab_Web_Page/index.html

 

Mailing Address

London Regional Cancer Program
Room A4-136, Cancer Research Laboratory Program
790 Commissioners Rd. E.
London, Ontario
Canada N6A 4L6

Tel: 519.685.8500 Ext 53027
Fax: 519.685.8616
Email: fdick@uwo.ca

Staff and Trainees

Graduate Students

Aren Marshall

Piru Perampalam

Seung Kim

Mike Roes

                                 
Staff

Daniel Passos     

James MacDonald  

Research Area

Cell Cycle and Genome Stability

Key Words

Cancer Genetics, Mouse Models of Cancer

Laboratory

Laboratory research is focused on the fundamental mechanisms that regulate the mammalian cell cycle and how they are disrupted in cancer. This is carried out by using cell culture, in vitro biochemical, and mouse gene-targeting technologies.

Summary of Current Work

Regulation of the mammalian cell division cycle is critical to development and disease.  Loss of proliferative control during development is catastrophic, as it can lead to genome instability, apoptosis, and tissue degeneration.  Loss of cell cycle control is also important in disease pathology, as deregulated proliferation is a defining feature of cancer.  A key regulator of progression through the G1 phase of the cell cycle is the pathway controlled by the Retinoblastoma protein (pRB).  It functions beyond G1-S control and has implications for cancer pathogenesis, treatment choice, and outcome.  We are investigating this multifaceted pathway.

 

PubMed Publications


See my publications on PubMed

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