Specialty Biochemistry

Division of Specialty Biochemistry

The Specialty Biochemistry laboratories have state of the art facilities and technology. To keep up with the pace of advanced techniques in laboratory medicine, we continue to add new tests and/or replace equipment as the need arises. We have many years of experience performing specialty tests such as immunosuppressant drug levels, autoantibody testing for autoimmune diseases, tumour marker and hormone testing, and trace elements testing, just to name a few.

The Specialty Biochemistry laboratories are composed of four main areas, each with its own specialty:

  • Clinical Immunology
  • Endocrinology
  • Toxicology and Therapeutic Drug Monitoring
  • Trace Elements

The Clinical Immunology laboratory specializes in performing protein electrophoresis and autoimmune antibody testing such as a comprehensive autoimmune encephalitis panel, a paraneoplastic antibody panel, a neuromyelitis spectrum profile, an autoimmune liver disease profile, and a myositis profile. We use various techniques such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA), including tissue immunohistochemistry and cell-based assays, immunoblot, and fluorescent enzyme immunoassay (FEIA).

The Endocrinology laboratory provides testing mostly for hormones and tumour markers. We have various platforms such as automated chemiluminescent and fluorescent immunoassay analyzers.

The Toxicology and Therapeutic Drug Monitoring laboratory offers a wide test menu of immunosuppressant/therapeutic drugs, drugs of abuse testing and confirmations, vitamin testing, renal stone analysis, and more. Our predominant methodologies are triple quadrupole liquid chromatography/mass spectrometry (LC/MS/MS), gas chromatography/mass spectrometry (GC/MS), and gas chromatography (GC).

The Trace Elements laboratory offers the widest range of trace element analysis for nutritional and toxic elements of clinical interest in Canada. Testing is used to assess deficiencies, measure nutrient intake, monitor toxic exposure through environmental or occupational exposure, and provide metal analysis for patients with orthopedic implants. We use high resolution sector field inductively coupled plasma mass spectrometry (HR-SF-ICP-MS) technology.


Division Head

Dr. Michael Knauer
519-685-8500, Extention. 52237


Vily Choperena
Special Biochemistry
519-685-8500, Extension. 64025

Section Head

Dr. Liju Yang
Clinical Immunology
519-685-8500, Extension. 35768

Section Head

Dr. Angela Rutledge
519-685-8500, Extension. 77626

Section Head

Dr. Matthew Nichols
Toxicology and Therapeutic Drug Monitoring / Trace Elements
519-685-8500, Extension. 64733

Section Head

Dr. Adrian Budhram
519-685-8500, Extension. 33615

Senior Technologist

Karen Gresty
Endocrinology, Clinical Immunology, Hemostasis and Thrombosis
519-685-8500, Extension. 76078

Senior Technologist

Cindy Iacobelli
Toxicology & Therapeutic Drug Monitoring,
Trace Elements and Biochemical Genetics
519-685-8500, Extension. 65748

Senior Technologist

LingBing Zhong
Toxicology & Therapeutic Drug Monitoring,
Trace Elements and Biochemical Genetics
519-685-8500, Extension. 56083

Senior Technologist

Erin Freeman
Endocrinology, Clinical Immunology and Investigational Hematology
519-685-8500, Extension. 36841