Hatim Fakir, Ph.D., MCCPM

 

Picture of Dr. Fakir

Medical Physicist, London Regional Cancer Program

Assistant Professor, Department of Oncology, Schulich School of Medicine & Dentistry, and Department of Medical Biophysics, Western University, Ontario.

 

Contact information:

London Health Sciences Centre
London Regional Cancer Program
Physics and Engineering Department
800 Commissioners Rd. E.
P.O. Box 5010, STN B
London, On N6A 5W9

Tel: 519-685-8500 Extension 54523
Fax: 519-685-8658
Email: hatim.fakir@lhsc.on.ca , hfakir@uwo.ca

 

 

Clinical interests:

  • Brain Radiosurgery
  • Stereotactic body radiotherapy (SBRT) with special focus on lung and prostate
  • Image guided radiotherapy and plan adaptation
     

Research interests:

  • Cancer progression and tumor growth modeling
  • Radiation induced DNA damage and repair
  • Cell survival and tumor control
  • Biology based optimization of radiation therapy protocols

 

Education and background:

Ph.D., Ibn Tofail University (Morocco), Nuclear physics.

PostDoc, Institut de Radioprotection et de Sûreté Nucléaire (France): Microdosimetry of alpha particles in lung.

PostDoc, Institute of Physics and Biophysics (Salzburg, Austria): Microdosimetry and radiation induced carcinogenesis.

Mathematical modeling of radiation-induced DNA damage and oncogenic transformations.

PostDoc, Center for Pure and Applied Mathematics, UC Berkeley (USA): Radiation-induced DNA damage, carcinogenesis, and tumor growth modeling.

 

 Selected publications:

  • Fakir H, Randhawa G, Millman B, Laba J. Improving geometric sparing and therapeutic effectiveness of lung SBRT for central and ultra-central tumors. Med Dosim. 2021 Jun 22;S0958-3947(21)00051-0.
  • Corkum M, Fakir H, Palma H, Nguyen T, Bauman G. Can Polymetastatic Disease Be ARRESTed Using SABR? A Dosimetric Feasibility Study to Inform Development of a Phase 1 Trial. Adv Radiat Oncl. 6(5):100734. 2021.
  • Bauman G, Corkum M, Fakir H, Nguyen T, Palma D. Ablative radiation therapy to restrain everything safely treatable (ARREST): study protocol for a phase I trial treating polymetastatic cancer with stereotactic radiotherapy. BMC Cancer. 14;21(1):405. 2021.
  • Goodman C, Fakir H and Bauman G. Dosimetric Evaluation of PSMA PET-delineated Dominant Intra-prostatic Lesion Simultaneous Infield Boosts. Adv Radiat Oncol. 5(2) (212-220), 2020.
  • Fakir H, Chen J, Sachs RK, Hypo-fractionated boost in locally advanced non-small cell lung cancer: temporal distribution of boost fractions. Phy. Med Biol. 63 (23), 2018.
  • Fakir H, Hlatky L, Li H, Sachs R. K. Repopulation of interacting tumor cells during fractionated radiotherapy: Stochastic modeling of the tumor control probability. Med Phys.40 (121716), 2013.

  • Fakir H, Gaede S, Mulligan M, Chen JZ. Development of a novel ArcCHECK(™) insert for routine quality assurance of VMAT delivery including dose calculation with inhomogeneities. Med Phys. 39: 4203-8, 2012

  • Fakir H., Hofmann W., Sachs R. K. Modeling progression in radiation-induced lung adenocarcinoma. Radiat. Environ Biophys. 49:169-76 (2010)

  • Fakir H, Tan W Y, Hlatky L, Hahnfeldt P and Sachs R K. Stochastic population dynamic effects for lung cancer progression. Radiat. Res. 172: 383-93 (2009)

  • Fakir H., Hofmann W., Tan W. Y., Sachs R. K. Triggering-response model for radiation induced bystander effects. Radiat. Res. 171: 320-331 (2009)

  • Fakir H, Hofmann W, Caswell RS. Radon progeny microdosimetry in Human and rat bronchial airways: the effect of crossfire from the alveolar region. Radiat. Prot. Dosimetry.130:149-161 (2008)

  • Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol.249: 518-31 (2007)

  • Fakir H., Sachs R. K., Stenerlöw B., and Hofmann, W. Clusters of DNA Double-Strand Breaks Induced by Nitrogen Ions for Varying LETs and Doses: Experimental Measurements and Theoretical Analyses. Radiat. Res. 166: 917:27 (2006)

  • Fakir H., Hofmann W. Incorporation of microdosimetric concepts into a biologically-based model of carcinogenesis. Radiat. Prot. Dosimetry.122:330-4 (2006)

  • Fakir H, Hofmann W, Aubineau-Laniece I. Modeling the effect of non-uniform radon progeny activities on transformation frequencies in human bronchial airways Radiat. Prot. Dosimetry, 121: 221-35 (2006).

  • Fakir H, Hofmann W, Aubineau-Laniece I., Microdosimetry of radon progeny alpha particles in bronchial airway bifurcations. Radiat Prot Dosimetry;117:382-94 (2006).

  • Fakir H, Hofmann W, Caswell RS, Aubineau-Laniece I. Microdosimetry of inhomogeneous radon progeny distributions in bronchial airways. Radiat Prot Dosimetry. 113:129-39 (2005).

  • Fakir H, Hofmann W., Aubineau-Laniece I., Caswell R. S., Jourdain J. R., Sabir A. Lung cancer risk in humans and rats: single vs. multiple exposures. In: McLaughlin J. P., Simopoulos S. E., Steinhäusler F., editors. The Natural Radiation Environment VII. Oxford: Elsevier. 1108-1115 (2005).