CLOXACILLIN

Disclaimer to the On-line Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.

CLOXACILLIN

Indication

  • A penicillin used to treat infections caused by susceptible strains of penicillinase-producing staphylococci (Staphylococcus aureus)

Dosage Guidelines

Meningitis

Postnatal Age

Weight (kg)

Dose

0 to 7 days

Less than 2

50 mg/kg/dose IV q 12h

2 or greater

50 mg/kg/dose IV q8h

Greater than 7 days

Less than 2

50 mg/kg/dose IV q8h

2 or greater

50 mg/kg/dose IV q6h

Sepsis and other infections

Postnatal Age

Weight (kg)

Dose

0 to 7 days

Less than 2

25 mg/kg/dose IV/oral q 12h

2 or greater

25 mg/kg/dose IV/oral q8h

Greater than 7 days

Less than 2

25 mg/kg/dose IV/oral q8h

2 or greater

25 mg/kg/dose IV/oral q6h

Administration

  • IV intermittent slow infusion over 30 minutes

To make 10 mL of a 50 mg/mL solution:

1. Reconstitution:  add 4.8 mL sterile water for injection to 500 mg vial (concentration = 100 mg/mL)

2. Draw up 5 mL of the 100 mg/mL reconstituted solution

3. Add 5 mL D5W to make a total volume of 10 mL (final concentration = 50 mg/mL)

  • IV direct over 3-5 minutes
  • Oral

Adverse Effects

  • Irritation at IV injection site

Comments

  • Incompatible with gentamicin; flush IV site well before administration
  • Oral suspension has a bitter taste

Supplied As

500 mg vial

50 mg/mL patient specific syringe, prepared by Pharmacy

25 mg/mL oral liquid

 

UPDATED:  March 2021