Disclaimer to the Online Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.
Cloxacillin
Indication
- A penicillin used to treat infections caused by susceptible strains of penicillinase-producing staphylococci (Staphylococcus aureus)
Dosage Guidelines
Meningitis:
Postnatal Age | Weight (kg) | Dose |
|---|---|---|
0 to 7 days | Less than 2 | 50 mg/kg/dose IV q 12h |
2 or greater | 50 mg/kg/dose IV q8h | |
Greater than 7 days | Less than 2 | 50 mg/kg/dose IV q8h |
2 or greater | 50 mg/kg/dose IV q6h |
Sepsis and other infections:
Postnatal Age | Weight (kg) | Dose |
|---|---|---|
0 to 7 days | Less than 2 | 25 mg/kg/dose IV/oral q 12h |
2 or greater | 25 mg/kg/dose IV/oral q8h | |
Greater than 7 days | Less than 2 | 25 mg/kg/dose IV/oral q8h |
2 or greater | 25 mg/kg/dose IV/oral q6h |
Administration
- IV intermittent slow infusion over 30 minutes
- How to make 10 mL of a 50 mg/mL solution:
- Reconstitution: add 4.8 mL sterile water for injection to 500 mg vial (concentration = 100 mg/mL)
- Draw up 5 mL of the 100 mg/mL reconstituted solution
- Add 5 mL sterile water to make a total volume of 10 mL (final concentration = 50 mg/mL)
- IV direct over 3-5 minutes
- Oral
Adverse Effects
- Irritation at IV injection site
Comments
- Incompatible with gentamicin; flush IV site well before administration
- Oral suspension has a bitter taste
Supplied As
- 500 mg vial
- 50 mg/mL patient specific syringe, prepared by Pharmacy
- 25 mg/mL oral liquid