- symptomatic management of gastrointestinal (GI) motility disorders and to treat gastroesophageal reflux disease
- domperidone is a peripheral dopamine type 2 receptor blocker and does not readily cross the blood brain barrier
- effects on the GI tract include increased lower esophageal sphincter pressure and increased esophageal peristalsis, increased gastric motility and peristalsis and enhanced gastroduodenal coordination
- insomnia, irritability, lethargy, dry mouth, gynecomastia, extrapyramidal symptoms (such as agitation, tremor and increased or decreased muscle movement) are rare
- QTc prolongation at higher doses, especially in patients with other risk factors such as other medications known to prolong QTc (for example chloral hydrate, ciprofloxacin, clarithromycin, dopamine, epinephrine, erythromycin, norepinephrine, salbutamol), hypokalemia or hyperkalemia, congenital long QT syndrome
- conditions in which stimulation of the GI tract may be dangerous (eg. gastrointestinal hemorrhage, NEC, mechanical obstruction or perforation, Hirschsprung's disease)
- monitor gastric residuals
- monitor for side effects as above
- neonates: 0.25mg/kg/dose po q8h or q6h
- infants greater than 40 weeks PCA and 28 days of life: 0.3-0.6 mg/kg/dose po TID or QID
- dilute oral solution with water or feeds just prior to administration
- 1 mg/mL oral suspension
- Domperidone monograph. Lexicomp online database, accessed online June 22, 2011 at http://online.lexi.com/crlsql/servlet/crlonline.
- Dailly E, Drouineau MH, Gournay V, Roze JC, Jolliet P. Population pharmacokinetics of domperidone in preterm neonates. Eur Jn Clin Pharmacol 2008 (64): 1197-1200.
- Gunlemez A, Babaoglu A, Arisoy AE, Turker G, Gokalp AS. Effect of domperidone on the QTc interval in premature infants. Journal of Perinatology 2010 (30): 50-53.
- Djeddi D, Kongolo G, Lefaix C, Mounard J, Leke A. Effect of Domperidone on QT Interval in Neonates. J Pediatr 2008: 153: 663-6.
|Prepared by:||Emily Ung, BScPhm||Date: June 22th, 2011|
David C. Knoppert, MScPhm
Date: June 23, 2011
Last Uploaded: May 2011