- Prophylaxis of urinary tract infections (UTI) in newborns with structural anomalies of the genitor-urinary tract
Trimethoprim (TMP) inhibits the enzyme dihydrofolate reductase (DHFR). DHFR catalyzes the reduction of dihydrofolate to tetrahydrofolate. Tetrahydrofolate is the active form of folic acid and is required in the biosynthesis of nucleic acids. TMP possesses a wide spectrum of activity against both gram positive and gram negative organisms.
Rash, hyperkalemia, hyponatremia, elevated liver enzymes, nausea, vomiting, elevated BUN and serum creatinine
1 mg/kg po q12h
(The rationale for giving trimethoprim in one evening dose is the long overnight dwell in the bladder in older children. Babies have no bladder control and just cycle the bladder when the intravesical pressure exceeds the opening pressure.)
10 mg/mL suspension (prepared with simple syrup - 85 % sucrose)
Stable for 30 days at Room temp
SHAKE WELL before using
- "Trimethoprim" in Lexi-Comp Online, accessed 18 Dec 2009.
- "Trimethoprim" in Micro Medex Online, accessed 18 Dec 2009.
Prepared by David Knoppert, Dec 2009
Reviewed by Dr Guido Filler, Dec 2009