Name: ETOMIDATE (AmidateR) Classification: sedative-hypnotic used as induction agent for intubation as general sedative or in rapid sequence induction rapid onset of action usually within 60 seconds (may be 5-15 seconds) with duration of action of 3-5 minutes (may be up to 14 minutes) no analgesic activity; minimal respiratory or cardiovascular effects special access product Dose: 0.3 mg/kg to usual maximum of 20 mg IV may require dose reduction in elderly patients Administration: IV direct over 30-60 seconds use large proximal arm veins or central line if possible to avoid pain on injection Adverse Effects: injection site pain transient skeletal muscle movements including myoclonus hypo-/hyperventilation, apnea arrhythmias laryngospasm nausea/vomiting prolonged suppression of cortisol and aldosterone synthesis with continuous infusion or repeated dosing Monitoring Therapy: continuous heart rate and rhythm blood pressure respiratory rate Oxygen saturation End-tidal CO2 Adult Critical Care Protocol: Must be administered by MD trained in airway management with patient specific approval from senior resident or CCTC consultant. monitoring sheet must be completed by administering physician and returned to Pharmacy Department. Lynne Kelly, Pharmacist, CCTC Brenda Morgan, Clinical Nurse Specialist, CCTC Last Reviewed: September 20, 2018
