PANTOPRAZOLE (Pantoloc)

• inhibits the gastric H KATPase enzyme (the proton pump) that is responsible for acid secretion by the parietal cells of the stomach, resulting in increased gastric pH 
• increased gastric pH desired for the prevention of stress-induced gastric ulceration and in the promotion of coagulation and platelet function in bleeding peptic ulcer disease 

• maintenance dose: 40 mg IV once daily or BID
• bleeding peptic ulcer:  80 mg IV bolus followed by continuous infusion at 8 mg/hr

• Bolus:  40-80 mg in 100 mL sodium chloride 0.9%, dextrose 5% or Ringer's Lacate infused over 15-60 minutes
• Infusion: 
  • 40 mg in 100 mL sodium chloride 0.9%, dextrose 5% or Ringer's Lacate
  • bag stable only for 6 hours; do not prepare large size bag

Neurological:

• headache, dizziness, lack of energy
• depression, insomnia or somnolence, nervousness
• paresthesia

Dermatologic:

• acne, edema
• puritis, maculopapular rash, urticaria
• exfoliative dermatitis
• alopecia

Gastrointestinal:

• diarrhea, constipation
• increased appetite, dry mouth

Musculoskeletal:

• weakness, muscle spasms
• arthralgia, tremors, numbness
• elevated creatinine kinase 

Ocular:

• photophobia

Renal/GU:

• hematuria
• impotence

• bowel movements, stools for occult blood
• skin condition

• May be administered IV direct or by IV infusion by a nurse in Adult Critical Care
• Continuous infusions must be administered by infusion device and the pump library must be enabled.