Name: PANTOPRAZOLE (PantolocR)
Classification: proton pump inhibitor (PPI) 
  • inhibits the gastric H KATPase enzyme (the proton pump) that is responsible for acid secretion by the parietal cells of the stomach, resulting in increased gastric pH 
  • increased gastric pH desired for the prevention of stress-induced gastric ulceration and in the promotion of coagulation and platelet function in bleeding peptic ulcer disease 
  • maintenance dose: 40 mg IV once daily or BID
  • bleeding peptic ulcer:  80 mg IV bolus followed by continuous infusion at 8 mg/hr
may need to decrease dose if significant hepatic dysfunction
  • Bolus:  40-80 mg in 100 mL sodium chloride 0.9%, dextrose 5% or Ringer's Lacate infused over 15-60 minutes
  • Infusion: 
    • 40 mg in 100 mL sodium chloride 0.9%, dextrose 5% or Ringer's Lacate
    • bag stable only for 6 hours; do not prepare large size bag
Adverse Effects:



  • headache, dizziness, lack of energy
  • depression, insomnia or somnolence, nervousness
  • paresthesia


  • acne, edema
  • puritis, maculopapular rash, urticaria
  • exfoliative dermatitis
  • alopecia



  • diarrhea, constipation
  • increased appetite, dry mouth


  • weakness, muscle spasms
  • arthralgia, tremors, numbness
  • elevated creatinine kinase 


  • photophobia


  • hematuria
  • impotence
Monitoring Therapy:
  • bowel movements, stools for occult blood
  • skin condition
CCTC Protocol:
  • May be administered IV direct or by IV infusion by a nurse in Adult Critical Care
  • Continuous infusions must be administered by infusion device and the pump library must be enabled.

Lynne Kelly, Pharmacist, CCTC
Brenda Morgan, Clinical Nurse Specialist, CCTC
Last Update: October 11, 2018