prolongs refractory period in atria and ventricles thus effective for arrhythmias of various origins
decreases SA automaticity and conduction through AV node
Multiple dosing regimes in literature; RECOMMEND:
150-300 mg IV (maximum infusion rate 30 mg/min)
900-1200 mg over 24 hours (37.5-50 mg per hour)
150 mg IV (maximum infusion rate 30 mg/min)
900 mg/500 ml dextrose 5% or sodium chloride 0.9% (1.8 mg/ml)
Continuous infusions should be prepared in non-PVC bags to prevent adsorption of amiodarone to bag.
Use of a 0.2 or 0.22 micron filter is recommended for intermittent and continuous infusions.
Bolus doses: in 100 ml D5W over 10 min (maximum infusion rate 30 mg/min)
Continuous infusion: in 500 ml D5W EXCEL bag over 24 hours
Cardiac Arrest (filter not required for cardiac arrest bolus dose):
First dose: Draw up amiodarone 300 mg (6 mL) into a 30 mL syringe, then draw up 24 mL of D5W. Administer the 30 mL solution as quickly as possible. Second dose: If patient remains in pulseless ventricular tachycardia or ventricular fibrillation 5 minutes after the first dose, give a second dose of amiodarone 150 mg (3 mL). Draw up into a 30 mL syringe, then draw up 27 mL of D5W. Administer the 30 mL solution as quickly as possible.
arrhythmias including radycardia and AV blocks
prolonged QT interval (with potential for Torsades des pointes)
hepatitis, elevation of liver function tests
peripheral myopathy or tremors, headache, sleep disturbances