extravasation of drug will cause tissue necrosis (Rx with 5-15 mg phentolamine in NS - see phentolamine monograph)
dopamine + IV phenytoin = decreased BP
dopamine + inhalational anaesthetics = increased risk of ventricular arrhythmias
dopamine + alpha blocking agents = blockade of inotropic effect
dopamine + beta blocking agents = blockade of inotropic effect
dopamine + other sympathomimetic agents = increased risk of toxicity
IV insertion site
continuous heart rate and ECG rhytym
changes in skin colour
central or mixed venous oxygen
cardiac index if being monitored
NOTE: although the use of dopamine has not been shown to improve renal function when it is administered for the sole purpose of stimulating dopaminergic receptors (low dose infusions), dopamine may indirectly improve renal function if it is administered at doses that improve cardiac ouptut.
Adult Critical Care Protocol:
May be given by IV infusion by a nurse in Adult Critical Care.
May be titrated by a nurse in Adult Critical Care.
Must be administered via central venous access device; in emergency situations dopamine may be temporarily infused through a peripheral vasuclar access device until a central venous line can be established.
Patient requires placement of an arterial line to monitor BP.
Continuous infusions must be administered by infusion device and the pump library must be enabled.
Should not be infused via the proximal injectate port (blue) of a pulmonary artery catheter. If this is the only available central venous line, it may be administered through the proximal injectate port but thermodilution cardiac output measurements must not be measured during infusion).
Lynne Kelly, Pharmacist, CCTC
Brenda Morgan, Clinical Nurse Specialist, CCTC Last Update: January 12, 2017, updated September 17, 2018