used in reversal of benzodiazepine induced CNS depression (will not necessarily reverse sedation or respiratory depression)
used in diagnosis and/or management of benzodiazepine overdose
Maximum cumulative dose is 3 mg. Patients with a partial response at 3 mg may required additional titration up to 5 mg. If no response 5 minutes after cumulative dose of 5 mg, the sedation is not likely due to benzodiazapines.
Benzodiazepine associated anaesthesia/sedation:
0.2 mg IV direct over 15 seconds
further incremental doses of 0.1 mg IV direct every 60 seconds to a maximum total dose of 1 mg
0.3 mg IV direct over 30 seconds
further incremental doses of 0.3 mg IV direct over 30 seconds repeated every 60 seconds to a cumulative dose of 3 mg
0.1 - 0.4 mg/hr, titrate to individual response. Indicated for rebound drowsiness.
1 mg/100 mL dextrose 5% or sodium chloride 0.9%
Due to abrupt benzodiazepine withdrawal:
cardiac arrhythmias including bradycardia or ventricular asystole